Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses

Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses

Summary: Activation of immune cells results in rapid functional changes, but how such fast changes are accomplished remains enigmatic. By combining time courses of 4sU-seq, RNA-seq, ribosome profiling (RP), and RNA polymerase II (RNA Pol II) ChIP-seq during T cell activation, we illustrate genome-wi...

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Bibliographic Details
Main Authors: Kathrin Davari, Johannes Lichti, Christian Gallus, Franziska Greulich, N. Henriette Uhlenhaut, Matthias Heinig, Caroline C. Friedel, Elke Glasmacher
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304461

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http://www.sciencedirect.com/science/article/pii/S2211124717304461

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