Doxorubicin Loaded PLGA Nanoparticle with Cationic/Anionic Polyelectrolyte Decoration: Characterization, and Its Therapeutic Potency

Doxorubicin Loaded PLGA Nanoparticle with Cationic/Anionic Polyelectrolyte Decoration: Characterization, and Its Therapeutic Potency

Optimized Doxorubicin hydrochloride (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (DPN) were prepared by controlling the water/oil distribution of DOX at different pH solutions and controlling the electrostatic interaction between DOX and different terminated-end PLGAs. Furthermore...

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Bibliographic Details
Main Authors: Li-Hui Tsai, Chia-Hsiang Yen, Hao-Ying Hsieh, Tai-Horng Young
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Polymers
Subjects:
doxorubicin
carboxylic acid terminated PLGA
ester terminated PLGA
polyethylenimine
poly(acrylic acid)
endo/lysosomal escape
Online Access:https://www.mdpi.com/2073-4360/13/5/693

Internet

https://www.mdpi.com/2073-4360/13/5/693

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