Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig

Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig

Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for testing and development of novel drugs. Here,...

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Bibliographic Details
Main Authors: Vanessa J. Hall, Maiken M. Lindblad, Jannik E. Jakobsen, Anders Gunnarsson, Mette Schmidt, Mikkel A. Rasmussen, Daniela Volke, Thole Zuchner, Poul Hyttel
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Alzheimer's disease
APP Swedish mutation
Pig
Radial glial cells
Astrocytes
Secretase expression
Tau phosphorylation
Cell cycle
Astrogenesis
Online Access:http://dmm.biologists.org/content/8/10/1265

Internet

http://dmm.biologists.org/content/8/10/1265

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