Comprehensive Genomic Characterization of Fifteen Early-Onset Lynch-Like Syndrome Colorectal Cancers

Comprehensive Genomic Characterization of Fifteen Early-Onset Lynch-Like Syndrome Colorectal Cancers

Lynch-like syndrome (LLS) is an increasingly common clinical challenge with an underlying molecular basis mostly unknown. To shed light onto it, we focused on a very young LLS early-onset colorectal cancer (CRC) cohort (diagnosis ≤ 40 y.o.), performing germline and tumor whole-exome sequencing (WES)...

Full description

Bibliographic Details
Main Authors: Mariano Golubicki, Marcos Díaz-Gay, Laia Bonjoch, Sebastià Franch-Expósito, Jenifer Muñoz, Miriam Cuatrecasas, Teresa Ocaña, Soledad Iseas, Guillermo Mendez, Marcela Carballido, Juan Robbio, Daniel Cisterna, Enrique Roca, Antoni Castells, Francesc Balaguer, Sergi Castellví-Bel, Marina Antelo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
colorectal cancer
biallelic somatic alteration
early-onset cancer
Lynch-like syndrome
mismatch repair
whole-exome sequencing
Online Access:https://www.mdpi.com/2072-6694/13/6/1259

Internet

https://www.mdpi.com/2072-6694/13/6/1259

Similar Items