Indoxyl Sulfate Mediates the Low Inducibility of the NLRP3 Inflammasome in Hemodialysis Patients

Indoxyl Sulfate Mediates the Low Inducibility of the NLRP3 Inflammasome in Hemodialysis Patients

The NLRP3 inflammasome is responsible for the maturation of caspase-1 and interleukin-1β (IL-1β). Despite the study about basal activity of the NLRP3 inflammasome in hemodialysis (HD) patients, little is known about its inducibility in the milieu of uremia. Peripheral blood mononuclear cells (PBMCs)...

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Bibliographic Details
Main Authors: Li-Chun Ho, Ting-Yun Wu, Tsun-Mei Lin, Hung-Hsiang Liou, Shih-Yuan Hung
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Toxins
Subjects:
NLRP3 inflammasome
indoxyl sulfate
uremia
innate immunity
Online Access:https://www.mdpi.com/2072-6651/13/1/38

Internet

https://www.mdpi.com/2072-6651/13/1/38

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