Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro

Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress, and canonical Smad3 pathway are implicated in the pathogenesis of cardiac fibrosis. We aim to investigate the protective roles of GE in isoproterenol (ISO)...

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Bibliographic Details
Main Authors: Ning Li, Heng Zhou, Zhen-Guo Ma, Jin-Xiu Zhu, Chen Liu, Peng Song, Chun-Yan Kong, Hai-Ming Wu, Wei Deng, Qi-Zhu Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
SIRT1
Geniposide
cardiac fibrosis
stress
Smad3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00854/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00854/full

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