Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells

Amplified in Breast Cancer Regulates Transcription and Translation in Breast Cancer Cells

Background: Control of mRNA translation is fundamentally altered in cancer. Insulin-like growth factor-I (IGF-I) signaling regulates key translation mediators to modulate protein synthesis (e.g. eIF4E, 4E-BP1, mTOR, and S6K1). Importantly the Amplified in Breast Cancer (AIB1) oncogene regulates tran...

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Bibliographic Details
Main Authors: Aleksandra M. Ochnik, Mark S. Peterson, Svetlana V. Avdulov, Annabell S. Oh, Peter B. Bitterman, Douglas Yee
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616000026

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http://www.sciencedirect.com/science/article/pii/S1476558616000026

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