Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation

Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation

Endothelial wingless-related integration site (Wnt)-/β-catenin signaling is a key regulator of the tightly sealed blood–brain barrier. In the hepatic vascular niche angiokine-mediated Wnt signaling was recently identified as an important regulator of hepatocyte function, including the determination...

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Bibliographic Details
Main Authors: Philipp-Sebastian Koch, Kajetan Sandorski, Joschka Heil, Christian D. Schmid, Sina W. Kürschner, Johannes Hoffmann, Manuel Winkler, Theresa Staniczek, Carolina de la Torre, Carsten Sticht, Kai Schledzewski, Makoto Mark Taketo, Felix A. Trogisch, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Victor Olsavszky
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
mice
liver
liver sinusoidal endothelial cells
endothelial cells
triglycerides
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.722394/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.722394/full

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