A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

Abstract Background Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to imp...

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Bibliographic Details
Main Authors: Ahrim Youn, Kyung In Kim, Raul Rabadan, Benjamin Tycko, Yufeng Shen, Shuang Wang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Medical Genomics
Subjects:
Pan-cancer analysis
TCGA
somatic mutation
DNA methylation
gene expression
methylation driver gene
Online Access:http://link.springer.com/article/10.1186/s12920-018-0425-z

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http://link.springer.com/article/10.1186/s12920-018-0425-z

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