The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome

The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome

T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual disability syndrome (TAF1 ID syndrome). Here, we evaluated the efficacy of a novel T-type Ca2+ channel enhancer, SAK3 (ethyl 8′-methyl-2′, 4-dioxo-...

Full description

Bibliographic Details
Main Authors: Udaiyappan Janakiraman, Chinnasamy Dhanalakshmi, Jie Yu, Aubin Moutal, Lisa Boinon, Kohji Fukunaga, Rajesh Khanna, Mark A. Nelson
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Neurobiology of Disease
Subjects:
TAF1
Intellectual disability syndrome
SAK3
Cav3.1
Cerebellum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302813

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120302813

Similar Items