Strategies to Overcome Resistance Mechanisms in T-Cell Acute Lymphoblastic Leukemia

Strategies to Overcome Resistance Mechanisms in T-Cell Acute Lymphoblastic Leukemia

Chemoresistance is a major cause of recurrence and death from T-cell acute lymphoblastic leukemia (T-ALL), both in adult and pediatric patients. In the majority of cases, drug-resistant disease is treated by selecting a combination of other drugs, without understanding the molecular mechanisms by wh...

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Bibliographic Details
Main Authors: Elena Follini, Matteo Marchesini, Giovanni Roti
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
T-ALL
resistance
chemotherapy
glucocorticoid
IL7R signaling
PI3K-AKT-mTOR inhibitors
NOTCH1 inhibitors
BET inhibitors
CDK4/6 inhibitors
BCL2 inhibitors
selective inhibitor of nuclear export (SINE)
DSRP
Online Access:https://www.mdpi.com/1422-0067/20/12/3021

Internet

https://www.mdpi.com/1422-0067/20/12/3021

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