Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

Abstract Background Nuclear Factor Erythroid-derived 2-like 2 (Nrf2) senses oxidative environments and/or stress and initiates a cytoprotective response through transcriptional activation of antioxidant and detoxification genes. Several preclinical studies suggest that Nrf2 combats oxidative stress...

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Bibliographic Details
Main Authors: Justin M. Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John R. Hoidal, Namakkal S. Rajasekaran
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Genomics
Subjects:
Nrf2
microRNA
mRNA
Heart
RNA sequencing
Differential expression
Online Access:http://link.springer.com/article/10.1186/s12864-017-3875-3

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