The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat

The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce significant damage to the small intestine, which is accompanied by changes in intestinal bacteria (dysbiosis) and bile acids. However, it is still a question of debate whether besides mucosal inflammation also other factors, such as di...

Full description

Bibliographic Details
Main Authors: Barbara Hutka, Bernadette Lázár, András S. Tóth, Bence Ágg, Szilvia B. László, Nóra Makra, Balázs Ligeti, Bálint Scheich, Kornél Király, Mahmoud Al-Khrasani, Dóra Szabó, Péter Ferdinandy, Klára Gyires, Zoltán S. Zádori
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
ketorolac
nonsteroidal anti-inflammatory drug
enteropathy
microbiota
bile acid
peristalsis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.664177/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.664177/full

Similar Items