p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita

p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita

Summary: Dyskeratosis congenita (DC) is a bone marrow failure syndrome associated with telomere dysfunction. The progression and molecular determinants of hematopoietic failure in DC remain poorly understood. Here, we use the directed differentiation of human embryonic stem cells harboring clinicall...

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Bibliographic Details
Main Authors: Wilson Chun Fok, Evandro Luis de Oliveira Niero, Carissa Dege, Kirsten Ann Brenner, Christopher Michael Sturgeon, Luis Francisco Zirnberger Batista
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302783

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http://www.sciencedirect.com/science/article/pii/S2213671117302783

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