Caffeine for the Pharmacological Treatment of Apnea of Prematurity in the NICU: Dose Selection Conundrum, Therapeutic Drug Monitoring and Genetic Factors

Caffeine for the Pharmacological Treatment of Apnea of Prematurity in the NICU: Dose Selection Conundrum, Therapeutic Drug Monitoring and Genetic Factors

Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of prematurity. Factors such as maturity and genetic variation contribute to the interindividual variability in the clinical response to caffeine therapy in preterm infants, making the optimal dose administered controv...

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Bibliographic Details
Main Authors: Jia-Yi Long, Hong-Li Guo, Xin He, Ya-Hui Hu, Ying Xia, Rui Cheng, Xuan-Sheng Ding, Feng Chen, Jing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
preterm infant
apnea of prematurity
caffeine
pharmacokinetics
therapeutic drug monitoring
polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.681842/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.681842/full

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