Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism

Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism

Attenuating the innate immunity activation could ameliorate inflammation and disease in settings such as transplant rejection or autoimmunity. Recently, a pivotal role for metabolic re-programming in TLR-induced dendritic cell (DC) activation has emerged. Ethyl pyruvate (EP), a pyruvate derivative,...

Full description

Bibliographic Details
Main Authors: Marita Chakhtoura, Robert W. Chain, Priscila Y. Sato, Connie C. Qiu, Michael H. Lee, Joseph J. Meissler, Toby K. Eisenstein, Walter J. Koch, Roberto Caricchio, Stefania Gallucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
ethyl pyruvate
TLR
DC activation
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00030/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00030/full

Similar Items