Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has shown that Ca2+/calmodulin-dependent protein kinase II (CaMKII) and myocyte-enhan...

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Bibliographic Details
Main Authors: Javier Duran, Daniel Lagos, Mario Pavez, Mayarling F. Troncoso, Sebastián Ramos, Genaro Barrientos, Cristian Ibarra, Sergio Lavandero, Manuel Estrada
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
CaMKII
MEF2C
testosterone
androgen receptor
cardiac myocyte
hypertrophy
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00604/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00604/full

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