Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite

Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite

Abstract Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have been shown to play a direct role. We adapted a CRISPR‐based proteomics approach to identify novel factors associated with var genes in their nat...

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Bibliographic Details
Main Authors: Jessica M Bryant, Sebastian Baumgarten, Florent Dingli, Damarys Loew, Ameya Sinha, Aurélie Claës, Peter R Preiser, Peter C Dedon, Artur Scherf
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Systems Biology
Subjects:
chromatin
CRISPR
epigenetics
Plasmodium falciparum
var genes
Online Access:https://doi.org/10.15252/msb.20209569

Internet

https://doi.org/10.15252/msb.20209569

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