Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort.

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort.

Pregnancy in women with systemic lupus erythematosus (SLE) or antiphospholipid antibodies (APL Ab)--autoimmune conditions characterized by complement-mediated injury--is associated with increased risk of preeclampsia and miscarriage. Our previous studies in mice indicate that complement activation t...

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Bibliographic Details
Main Authors: Jane E Salmon, Cara Heuser, Michael Triebwasser, M Kathryn Liszewski, David Kavanagh, Lubka Roumenina, D Ware Branch, Tim Goodship, Veronique Fremeaux-Bacchi, John P Atkinson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC3062534?pdf=render

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http://europepmc.org/articles/PMC3062534?pdf=render

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