Molecular Genetics Analysis of 70 Chinese Families With Muscular Dystrophy Using Multiplex Ligation-Dependent Probe Amplification and Next-Generation Sequencing

Molecular Genetics Analysis of 70 Chinese Families With Muscular Dystrophy Using Multiplex Ligation-Dependent Probe Amplification and Next-Generation Sequencing

Background: Muscular dystrophy (MD) includes multiple types, of which dystrophinopathies caused by dystrophin (DMD) mutations are the most common types in children. An accurate identification of the causative mutation at the genomic level is critical for genetic counseling of the family, and analysi...

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Bibliographic Details
Main Authors: Dong Wang, Min Gao, Kaihui Zhang, Ruifeng Jin, Yuqiang Lv, Yong Liu, Jian Ma, Ya Wan, Zhongtao Gai, Yi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
muscular dystrophy
multiplex ligation-dependent probe amplification
next-generation sequencing
dystrophin (DMD)
merosin-deficient congenital muscular dystrophy type 1A
LAMA2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00814/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00814/full

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