Development of a High-Throughput ex-Vivo Burn Wound Model Using Porcine Skin, and Its Application to Evaluate New Approaches to Control Wound Infection

Development of a High-Throughput ex-Vivo Burn Wound Model Using Porcine Skin, and Its Application to Evaluate New Approaches to Control Wound Infection

Biofilm formation in wounds is considered a major barrier to successful treatment, and has been associated with the transition of wounds to a chronic non-healing state. Here, we present a novel laboratory model of wound biofilm formation using ex-vivo porcine skin and a custom burn wound array devic...

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Bibliographic Details
Main Authors: Diana R. Alves, Simon P. Booth, Paola Scavone, Pascale Schellenberger, Jonathan Salvage, Cinzia Dedi, Naing-Tun Thet, A. Toby A. Jenkins, Ryan Waters, Keng W. Ng, Andrew D. J. Overall, Anthony D. Metcalfe, Jonathan Nzakizwanayo, Brian V. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ex-vivo burn wound model
infection
Staphylococcus aureus
bacteriophage therapy
biofilm
accessory gene regulator
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00196/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00196/full

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