Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRNA-induced covariation of target mRNAs.

Bibliographic Details
Main Authors: Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19011-5

Internet

https://doi.org/10.1038/s41467-020-19011-5

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