Novel naphthalene-enoates: Design and anticancer activity through regulation cell autophagy

Eleven dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene derivatives as anticancer agents through regulating cell autophagy were designed and synthesized. The anticancer activity results indicated that most compounds manifested obvious un-toxic effect on GES-1 and L-02 with IC50 from 0.58 to 1....

Full description

Bibliographic Details
Main Authors: Meng Di Yang, Xiao Bao Shen, Yang Sheng Hu, Yan Yan Chen, Xin Hua Liu
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219306869