Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation

Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation

Summary: Bub1 is required for the kinetochore/centromere localization of two essential mitotic kinases Plk1 and Aurora B. Surprisingly, stable depletion of Bub1 by ∼95% in human cells marginally affects whole chromosome segregation fidelity. We show that CENP-U, which is recruited to kinetochores by...

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Bibliographic Details
Main Authors: Qinfu Chen, Miao Zhang, Xuan Pan, Xueying Yuan, Linli Zhou, Lu Yan, Ling-Hui Zeng, Junfen Xu, Bing Yang, Long Zhang, Jun Huang, Weiguo Lu, Tatsuo Fukagawa, Fangwei Wang, Haiyan Yan
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
Bub1
CENP-U
Plk1
kinetochore
kinetochore-microtubule attachment
chromosome alignment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011931

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http://www.sciencedirect.com/science/article/pii/S2211124721011931

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