Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study

Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study

Following the introduction of immune checkpoint inhibitors, a substantial prolongation of the overall survival has been achieved for many patients with multiple brain metastases from melanoma. However, heterogeneity between individual tumor responses is incompletely understood. In order to determine...

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Bibliographic Details
Main Authors: Arnulf Mayer, Maximilian Haist, Carmen Loquai, Stephan Grabbe, Matthias Rapp, Wilfried Roth, Peter Vaupel, Heinz Schmidberger
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
hypoxia
adenosine
tumor microenvironment
immunosuppression
multiplex immunohistochemistry
spatial statistics
Online Access:https://www.mdpi.com/2072-6694/12/12/3753

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https://www.mdpi.com/2072-6694/12/12/3753

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