B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2

B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2

Summary: Plasma cells secreting affinity-matured antibodies develop in germinal centers (GCs), where B cells migrate persistently and directionally over defined periods of time. How modes of GC B cell migration influence plasma cell development remained unclear. Through genetic deletion of the F-act...

Full description

Bibliographic Details
Main Authors: Dorothea Reimer, Michael Meyer-Hermann, Asylkhan Rakhymzhan, Tobit Steinmetz, Philipp Tripal, Jana Thomas, Martin Boettcher, Dimitrios Mougiakakos, Sebastian R. Schulz, Sophia Urbanczyk, Anja E. Hauser, Raluca A. Niesner, Dirk Mielenz
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
Swiprosin-1/EFhd2
germinal center
migration
follicular dendritic cell
actin cytoskeleton
B cell receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310159

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720310159

Similar Items