Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-18569-4 |
id |
doaj-1b3e75d138fe4626bae55cdc8321e3d1 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger |
spellingShingle |
Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression Nature Communications |
author_facet |
Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger |
author_sort |
Astrid De Boeck |
title |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
title_short |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
title_full |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
title_fullStr |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
title_full_unstemmed |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
title_sort |
glioma-derived il-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-10-01 |
description |
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells. |
url |
https://doi.org/10.1038/s41467-020-18569-4 |
work_keys_str_mv |
AT astriddeboeck gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT boyoungahn gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT charlottedmello gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT xueqinglun gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT shyamvmenon gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT manamalshehri gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT frankszulzewsky gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT yaoqingshen gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT lubabakhan gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT ngochadang gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT elliottreichardt gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT kimberlyanngoring gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT jenniferking gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT cameronjgrisdale gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT nataliegrinshtein gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT doloreshambardzumyan gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT karlynemreilly gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT michaeldblough gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT jgregorycairncross gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT vweeyong gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT marcoamarra gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT stevenjmjones gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT davidrkaplan gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT kathydmccoy gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT ericcholland gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT pinakibose gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT jenniferachan gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT stephenmrobbins gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression AT donnalsenger gliomaderivedil33orchestratesaninflammatorybraintumormicroenvironmentthatacceleratesgliomaprogression |
_version_ |
1716829488715661312 |
spelling |
doaj-1b3e75d138fe4626bae55cdc8321e3d12021-10-10T11:47:47ZengNature Publishing GroupNature Communications2041-17232020-10-0111112410.1038/s41467-020-18569-4Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progressionAstrid De Boeck0Bo Young Ahn1Charlotte D’Mello2Xueqing Lun3Shyam V. Menon4Mana M. Alshehri5Frank Szulzewsky6Yaoqing Shen7Lubaba Khan8Ngoc Ha Dang9Elliott Reichardt10Kimberly-Ann Goring11Jennifer King12Cameron J. Grisdale13Natalie Grinshtein14Dolores Hambardzumyan15Karlyne M. Reilly16Michael D. Blough17J. Gregory Cairncross18V. Wee Yong19Marco A. Marra20Steven J. M. Jones21David R. Kaplan22Kathy D. McCoy23Eric C. Holland24Pinaki Bose25Jennifer A. Chan26Stephen M. Robbins27Donna L. Senger28Clark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryDivison of Human Biology, Fred Hutchinson Cancer Research CenterCanada’s Michael Smith Genome Sciences Centre, British Columbia Cancer AgencyClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryCanada’s Michael Smith Genome Sciences Centre, British Columbia Cancer AgencyDepartment of Molecular Genetics, University of Toronto and Program in Neurosciences and Mental Health, Hospital for Sick ChildrenDepartment of Oncological Sciences, The Tisch Cancer Institute and the Department of Neurosurgery, Icahn School of Medicine at Mount SinaiCenter for Cancer Research, National Cancer InstituteClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryDepartment of Clinical Neurosciences, Cumming School of Medicine, University of CalgaryCanada’s Michael Smith Genome Sciences Centre, British Columbia Cancer AgencyCanada’s Michael Smith Genome Sciences Centre, British Columbia Cancer AgencyDepartment of Molecular Genetics, University of Toronto and Program in Neurosciences and Mental Health, Hospital for Sick ChildrenDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of CalgaryDivison of Human Biology, Fred Hutchinson Cancer Research CenterClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryClark Smith Brain Tumour Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryElevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.https://doi.org/10.1038/s41467-020-18569-4 |