Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.
Main Authors: | Astrid De Boeck, Bo Young Ahn, Charlotte D’Mello, Xueqing Lun, Shyam V. Menon, Mana M. Alshehri, Frank Szulzewsky, Yaoqing Shen, Lubaba Khan, Ngoc Ha Dang, Elliott Reichardt, Kimberly-Ann Goring, Jennifer King, Cameron J. Grisdale, Natalie Grinshtein, Dolores Hambardzumyan, Karlyne M. Reilly, Michael D. Blough, J. Gregory Cairncross, V. Wee Yong, Marco A. Marra, Steven J. M. Jones, David R. Kaplan, Kathy D. McCoy, Eric C. Holland, Pinaki Bose, Jennifer A. Chan, Stephen M. Robbins, Donna L. Senger |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-18569-4 |
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