Association testing to detect gene-gene interactions on sex chromosomes in trio data

Association testing to detect gene-gene interactions on sex chromosomes in trio data

Autism Spectrum Disorder (ASD) occurs more often among males than females in a 4:1 ratio. Among theories used to explain the causes of ASD, the X chromosome and the Y chromosome theories attribute ASD to X-linked mutation and the male-limited gene expressions on the Y chromosome, respectively. Despi...

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Bibliographic Details
Main Authors: Yeonok eLee, Debashis eGhosh, Yu eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Genetics
Subjects:
Sex Chromosomes
gene-gene interaction
binary traits
generalized linear mixed effect model
logistic model
trio data
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00239/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00239/full

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