SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.

SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.

BACKGROUND: FOXL2 is a transcription factor essential for ovarian development and maintenance. It is mutated in the genetic condition called Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES) and in cases of isolated premature ovarian failure. We and others have previously shown that FOXL2 u...

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Bibliographic Details
Main Authors: Adrien Georges, Bérénice A Benayoun, Mara Marongiu, Aurélie Dipietromaria, David L'Hôte, Anne-Laure Todeschini, Jana Auer, Laura Crisponi, Reiner A Veitia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192040?pdf=render

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http://europepmc.org/articles/PMC3192040?pdf=render

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