Trinucleotide Base Pair Stacking Free Energy for Understanding TF-DNA Recognition and the Functions of SNPs

Trinucleotide Base Pair Stacking Free Energy for Understanding TF-DNA Recognition and the Functions of SNPs

Single nucleotide polymorphisms (SNPs) affect base pair stacking, which is the primary factor for maintaining the stability of DNA. However, the mechanism of how SNPs lead to phenotype variations is still unclear. In this work, we connected SNPs and base pair stacking by a 3-mer base pair stacking f...

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Bibliographic Details
Main Authors: Gen Li, Yuan Quan, Xiaocong Wang, Rong Liu, Lihua Bie, Jun Gao, Hong-Yu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Chemistry
Subjects:
base stacking
free energy
single nucleotide polymorphisms
molecular dynamics simulation
binding specificity
transcription factor
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00666/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00666/full

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