ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling

ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling

Abstract Background Regulator of cullins 1 (ROC1) is an important catalytic subunit of cullin–RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling is closely related to tumor invasion and metastasis. Earlier, we reported that ROC1 was associated with a poor prognosis in patients with bladder can...

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Bibliographic Details
Main Authors: Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ROC1
NF-κB
Ubiquitination
Metastasis
Bladder cancer
Online Access:https://doi.org/10.1186/s13046-021-01935-5

Internet

https://doi.org/10.1186/s13046-021-01935-5

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