Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice

Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice

Pentavalent antimonials such as meglumine antimoniate (MA) are the primary treatments for leishmaniasis, a complex disease caused by protozoan parasites of the genus Leishmania . Despite over 70 years of clinical use, their mechanisms of action, toxicity and pharmacokinetics have not been fully eluc...

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Bibliographic Details
Main Authors: Samanta Etel Treiger Borborema, João Alberto Osso Junior, Heitor Franco de Andrade Junior, Nanci do Nascimento
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2013-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
leishmaniasis
glucantime
radioisotope
antimony
biodistribution
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000500623&lng=en&tlng=en

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