DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

DNA damage and alterations in the DNA damage response (DDR) are critical sources of genetic instability that might be involved in BCR-ABL1 kinase-mediated blastic transformation of chronic myeloid leukemia (CML). Here, increased DNA damage is detected by γH2AX foci analysis in peripheral bl...

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Bibliographic Details
Main Authors: Henning D. Popp, Vanessa Kohl, Nicole Naumann, Johanna Flach, Susanne Brendel, Helga Kleiner, Christel Weiss, Wolfgang Seifarth, Susanne Saussele, Wolf-Karsten Hofmann, Alice Fabarius
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
chronic myeloid leukemia
genetic instability
dna double-strand breaks
dna damage response
Online Access:https://www.mdpi.com/1422-0067/21/4/1177

Internet

https://www.mdpi.com/1422-0067/21/4/1177

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