The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure

<p>Abstract</p> <p>Background</p> <p>We have recently discovered that the two tryptophans of human β2-microglobulin have distinctive roles within the structure and function of the protein. Deeply buried in the core, Trp95 is essential for folding stability, whereas Trp6...

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Bibliographic Details
Main Authors: Monti Maria, Bellazzi Riccardo, Soria Cristina, Marchese Loredana, Zorzoli Irene, Bolognesi Martino, Ricagno Stefano, Esposito Gennaro, Mangione Palma, Barbarini Nicola, Raimondi Sara, Stoppini Monica, Stefanelli Mario, Magni Paolo, Bellotti Vittorio
Format: Article
Language:English
Published: BMC 2011-06-01
Series:BMC Evolutionary Biology
Online Access:http://www.biomedcentral.com/1471-2148/11/159

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http://www.biomedcentral.com/1471-2148/11/159

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