Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway

Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway

The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol (HT) and its main plasmatic metabolites (HTmet) that improve the endothelial function. Feeding ApoE−/− mice with 10 mg/kg/day of HT derivatives for 12 weeks significantly reduced E-selectin, VCAM-1, MCP-1, I...

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Bibliographic Details
Main Authors: Úrsula Catalán, Maria-Carmen López de las Hazas, Carmen Piñol, Laura Rubió, Maria-José Motilva, Sara Fernandez-Castillejo, Rosa Solà
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Functional Foods
Subjects:
Hydroxytyrosol
Hydroxytyrosol metabolites
Atherosclerosis
ApoE−/−mice
Human aortic endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617306795

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http://www.sciencedirect.com/science/article/pii/S1756464617306795

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