PTEN loss correlates with T cell exclusion across human cancers

PTEN loss correlates with T cell exclusion across human cancers

Abstract Background Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN loss on tumor microenvironment, espec...

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Bibliographic Details
Main Authors: Ziying Lin, Lixia Huang, Shao Li Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
PTEN
PI3K signaling
Tumor immune microenvironment
T cells
Immunotherapy
Online Access:https://doi.org/10.1186/s12885-021-08114-x

Internet

https://doi.org/10.1186/s12885-021-08114-x

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