Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives

Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives

The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of...

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Bibliographic Details
Main Authors: Hiroyuki Masuno, Teikichi Ikura, Daisuke Morizono, Isamu Orita, Sachiko Yamada, Masato Shimizu, Nobutoshi Ito
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Journal of Lipid Research
Subjects:
nuclear receptor
structure-function relationship
bile acid
hypercalcemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375362

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http://www.sciencedirect.com/science/article/pii/S0022227520375362

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