A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

A human-like bile acid pool induced by deletion of hepatic Cyp2c70 modulates effects of FXR activation in mice[S]

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5. These receptors are targets for therapy in cholestatic and metabolic diseases. However, dissimilarities...

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Bibliographic Details
Main Authors: Jan Freark de Boer, Esther Verkade, Niels L. Mulder, Hilde D. de Vries, Nicolette Huijkman, Martijn Koehorst, Theo Boer, Justina C. Wolters, Vincent W. Bloks, Bart van de Sluis, Folkert Kuipers
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of Lipid Research
Subjects:
liver
humanized mouse model
cholesterol
transintestinal cholesterol excretion
cytochrome P450 family 2 subfamily c polypeptide 70
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752043514X

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http://www.sciencedirect.com/science/article/pii/S002222752043514X

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