TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to pluripotency genes, thereby exerting vast epi...

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Bibliographic Details
Main Authors: Rosa María Marión, Juan J Montero, Isabel López de Silanes, Osvaldo Graña-Castro, Paula Martínez, Stefan Schoeftner, José Alejandro Palacios-Fábrega, Maria A Blasco
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
TRF1
telomere
pluripotency
TERRA
polycomb
lncRNA
Online Access:https://elifesciences.org/articles/44656

Internet

https://elifesciences.org/articles/44656

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