Immunization With the CSF-470 Vaccine Plus BCG and rhGM-CSF Induced in a Cutaneous Melanoma Patient a TCRβ Repertoire Found at Vaccination Site and Tumor Infiltrating Lymphocytes That Persisted in Blood

Immunization With the CSF-470 Vaccine Plus BCG and rhGM-CSF Induced in a Cutaneous Melanoma Patient a TCRβ Repertoire Found at Vaccination Site and Tumor Infiltrating Lymphocytes That Persisted in Blood

The CSF-470 cellular vaccine plus BCG and rhGM-CSF increased distant metastases-free survival in cutaneous melanoma patients stages IIB-IIC-III relative to medium dose IFN-α2b (CASVAC-0401 study). Patient-045 developed a mature vaccination site (VAC-SITE) and a regional cutaneous metastasis (C-MTS),...

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Bibliographic Details
Main Authors: Mariana Aris, Alicia Inés Bravo, Heli Magalí Garcia Alvarez, Ibel Carri, Enrique Podaza, Paula Alejandra Blanco, Cecilia Rotondaro, Sofia Bentivegna, Morten Nielsen, María Marcela Barrio, José Mordoh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
cutaneous melanoma
CSF-470 vaccine
vaccination site
cutaneous metastasis
tumor infiltrating lymphocytes
TCRβ repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02213/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02213/full

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