SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury

SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury

Abstract Background Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis of SCs as well as the fate of peripheral nerve regeneration. However,...

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Bibliographic Details
Main Authors: Jiang-Bo Wang, Zhan Zhang, Jian-Nan Li, Tuo Yang, Shuang Du, Rang-Juan Cao, Shu-Sen Cui
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cell & Bioscience
Subjects:
Peripheral nerve injury
SPP1
PKCα
CD44
αvβ3
Schwann cells
Online Access:http://link.springer.com/article/10.1186/s13578-020-00458-4

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http://link.springer.com/article/10.1186/s13578-020-00458-4

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