A first report of a rare TP53 variant associated with Li-Fraumeni syndrome manifesting as invasive breast cancer and malignant solitary fibrous tumor

A first report of a rare TP53 variant associated with Li-Fraumeni syndrome manifesting as invasive breast cancer and malignant solitary fibrous tumor

Abstract Background Li-Fraumeni is a rare autosomal dominant cancer predisposition syndrome. The basis is a germline mutation of TP53 gene which encodes tumor suppressor protein resulting in early onset of tumors, most often breast cancer, soft tissue sarcomas, brain tumors, adrenocortical carcinoma...

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Bibliographic Details
Main Authors: Juraj Prejac, Natalija Dedić Plavetić, Kristina Gotovac Jerčić, Fran Borovečki
Format: Article
Language:English
Published: BMC 2021-08-01
Series:World Journal of Surgical Oncology
Subjects:
TP53
Li-Fraumeni syndrome
Invasive breast cancer
Malignant solitary fibrous tumor
Splice-site mutation
Online Access:https://doi.org/10.1186/s12957-021-02370-8

Internet

https://doi.org/10.1186/s12957-021-02370-8

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