The use of a predictive statistical model to make a virtual control arm for a clinical trial.

<h4>Background</h4>Randomized clinical trials compare participants receiving an experimental intervention to participants receiving standard of care (SOC). If one could predict the outcome for participants receiving SOC, a trial could be designed where all participants received the exper...

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Bibliographic Details
Main Authors: Jeffrey M Switchenko, Arielle L Heeke, Tony C Pan, William L Read
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221336