Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution.

MicroRNA (miRNA)-mediated gene regulation is of critical functional importance in animals and is thought to be largely constrained during evolution. However, little is known regarding evolutionary changes of the miRNA network and their role in human evolution. Here we show that a number of miRNA bin...

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Bibliographic Details
Main Authors: Jingjing Li, Yu Liu, Xiaofeng Xin, Taehyung Simon Kim, Eduardo Aguiar Cabeza, Jie Ren, Rasmus Nielsen, Jeffrey L Wrana, Zhaolei Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3310733?pdf=render