Pre-Existing Humoral Immunity Enhances Epicutaneously-Administered Allergen Capture by Skin DC and Their Migration to Local Lymph Nodes

Pre-Existing Humoral Immunity Enhances Epicutaneously-Administered Allergen Capture by Skin DC and Their Migration to Local Lymph Nodes

Due to its richness in antigen presenting cells, e.g., dendritic cells (DC), the skin has been identified as a promising route for immunotherapy and vaccination. Several years ago, a skin delivery system was developed based on epicutaneous patches allowing the administration of antigen through intac...

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Bibliographic Details
Main Authors: Pierre-Louis Hervé, Camille Plaquet, Noémie Assoun, Nathalie Oreal, Laetitia Gaulme, Audrey Perrin, Adeline Bouzereau, Véronique Dhelft, Jean-Louis Labernardière, Lucie Mondoulet, Hugh A. Sampson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
skin dendritic cells
epicutaneous delivery
allergen capture
Fc receptors (FcR)
preexisting immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.609029/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.609029/full

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