Neoplastic Cells are the Major Source of MT-MMPs in <i>IDH1</i>-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration

Neoplastic Cells are the Major Source of MT-MMPs in <i>IDH1</i>-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration

Tumor-cell infiltration is a major obstacle to successful therapy for brain tumors. Membrane-type matrix metalloproteinases (MT-MMPs), a metzincin subfamily of six proteases, are important mediators of infiltration. The cellular source of MT-MMPs and their role in glioma biology, however, remain con...

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Bibliographic Details
Main Authors: Ina Thome, Raphael Lacle, Andreas Voß, Ginette Bortolussi, Georgios Pantazis, Ansgar Schmidt, Catharina Conrad, Ralf Jacob, Nina Timmesfeld, Jörg W. Bartsch, Axel Pagenstecher
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
matrix metalloproteases
glioma
isocitrate dehydrogenase
organotypic cell invasion assay
invasion
Online Access:https://www.mdpi.com/2072-6694/12/9/2456

Internet

https://www.mdpi.com/2072-6694/12/9/2456

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