Acquired Hemophilia A in IgG4-Related Disease: Case Report, Immunopathogenic Study, and Review of the Literature

Acquired Hemophilia A in IgG4-Related Disease: Case Report, Immunopathogenic Study, and Review of the Literature

We report the observation of a 75-year-old patient referred for cervical lymphadenopathies. A pre-lymphadenectomy blood work revealed an asymptomatic elevation of aPTT with low factor VIII (FVIII) levels and high anti-FVIII antibodies titers, consistent with acquired hemophilia A (AHA). Histological...

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Bibliographic Details
Main Authors: Sébastien Sanges, Emmanuelle Jeanpierre, Benjamin Lopez, Jules Russick, Sandrine Delignat, Benjamin Carpentier, Romain Dubois, Sylvain Dubucquoi, Thomas Guerrier, Éric Hachulla, Pierre-Yves Hatron, Camille Paris, Sophie Susen, David Launay, Sébastien Lacroix-Desmazes, Louis Terriou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
anti-factor VIII autoantibodies
IgG4 antibodies
acquired hemophilia A
IgG4-related disease
plasma cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.558811/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.558811/full

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