Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier

Anti-microRNA oligonucleotides (AMOs) are steric blocking antisense reagents that inhibit microRNA (miRNA) function by hybridizing and repressing the activity of a mature miRNA. First generation AMOs employed 2′-O-Methyl RNA nucleotides (2′OMe) with phosphorothioate (PS) internucleotide linkages pos...

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Bibliographic Details
Main Authors: Kim A Lennox, Richard Owczarzy, Derek M Thomas, Joseph A Walder, Mark A Behlke
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
AMO
antagomir
anti-miRNA
antisense
miRNA
oligonucleotide
RNAi
ZEN
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301767

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http://www.sciencedirect.com/science/article/pii/S2162253116301767

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