Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins

Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins

PD-1/PD-L1 blockade has revolutionized the field of immunooncology. Despite the relative success, the response rate to anti-PD-1 therapy requires further improvements. Our aim was to explore the enhancement of T-cell function by using novel PD-1-blocking proteins and compare with clinically approved...

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Bibliographic Details
Main Authors: Emelie Foord, Charlotte Klynning, Esther Schoutrop, Judith M. Förster, Jennifer Krieg, Anette Mörtberg, Mischa R. Müller, Christel Herzog, Dieter Schiegg, Denis Villemagne, Ulrike Fiedler, Dan Snell, Benjamin Kebble, Jonas Mattsson, Victor Levitsky, Michael Uhlin
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2020/7375947

Internet

http://dx.doi.org/10.1155/2020/7375947

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